An efficient synthesis of 6-arylbenzo[4,5]imidazo[2,1-a]isoquinolines via sequential α-arylation of carbonyl and deacylation catalyzed by CuI-Reference-Cited by-同舟云学术

An efficient synthesis of 6-arylbenzo[4,5]imidazo[2,1-a]isoquinolines via sequential α-arylation of carbonyl and deacylation catalyzed by CuI

Published:2017 Issue:25 Volume:15 Page:5325-5331
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Miao Wei-Qing¹²³⁴⁵,Liu Jian-Quan¹²³⁴⁵,Wang Xiang-Shan¹²³⁴⁵^ORCID

Affiliation:

1. School of Chemistry and Chemical Engineering

2. Jiangsu Key Laboratory of Green Synthesis for Functional Materials

3. Jiangsu Normal University

4. Xuzhou

5. P. R. China

Abstract

Dibenzoyl methane was found to undergo α-arylation of carbonyl and deacylation reaction with 2-(2-bromophenyl)-1H-benzo[d]imidazoles catalyzed by CuI in the presence of Cs₂CO₃, and provided an efficient synthesis of 6-arylbenzo[4,5]imidazo[2,1-a]isoquinolines.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01022B

Reference33 articles.

1. Proton Pump Inhibitors

2. Lifitegrast Ophthalmic Solution 5.0% versus Placebo for Treatment of Dry Eye Disease

3. AgI-Catalyzed Cascade Strategy: Regioselective Access to Diversely Substituted Fused Benzimidazo[2,1-a]isoquinolines, Naphthyridines, Thienopyridines, and Quinoxalines in Water

4. Highly efficient Ag(i)-catalyzed regioselective tandem synthesis of diversely substituted quinoxalines and benzimidazoles in water

5. Oxidative Heterocyclization of 2-Alkynylbenzaldehydes with 1,2-Phenylenediamine

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