A 3D-printed microfluidic gradient generator with integrated photonic silicon sensors for rapid antimicrobial susceptibility testing

Author:

Heuer Christopher12ORCID,Preuss John-Alexander13ORCID,Buttkewitz Marc1,Scheper Thomas1,Segal Ester2ORCID,Bahnemann Janina13ORCID

Affiliation:

1. Institute of Technical Chemistry, Leibniz University Hannover, 30167 Hannover, Germany

2. Department of Biotechnology and Food Engineering, Technion – Israel Institute of Technology, 320003 Haifa, Israel

3. Institute of Physics, University of Augsburg, 86159 Augsburg, Germany

Abstract

A 3D-printed gradient generator for automated and expeditious on-chip antimicrobial susceptibility testing in a label-free manner is presented, paving the way towards clinical point-of-care applications.

Funder

Deutsche Forschungsgemeinschaft

Volkswagen Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Reference76 articles.

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2. Multitarget Approaches against Multiresistant Superbugs

3. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

4. Interagency Coordination Group on Antimicrobial Resistance, No time to wait: Securing the future from drug-resistant infections. Report to the secretary-general of the United Nations, https://www.who.int/docs/default-source/documents/no-time-to-wait-securing-the-future-from-drug-resistant-infections-en.pdfsfvrsn=5b424d7_6 , (accessed 17 June 2022)

5. Antimicrobial Stewardship

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