Ion mobility-mass spectrometry shows stepwise protein unfolding under alkaline conditions-Reference-Cited by-同舟云学术

Ion mobility-mass spectrometry shows stepwise protein unfolding under alkaline conditions

Published:2021 Issue:12 Volume:57 Page:1450-1453
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Sahin Cagla¹²³⁴⁵^ORCID,Österlund Nicklas⁶⁷⁸⁵⁹^ORCID,Leppert Axel¹⁰³¹¹⁵,Johansson Jan¹⁰³¹¹⁵,Marklund Erik G.¹²¹³¹⁴¹⁵⁵^ORCID,Benesch Justin L. P.¹⁶¹⁷¹⁸¹⁹²⁰,Ilag Leopold L.⁹⁷⁸⁵,Allison Timothy M.²¹²²²³²⁴^ORCID,Landreh Michael¹²³⁴⁵^ORCID

Affiliation:

1. Department of Microbiology

2. Tumor and Cell Biology

3. Karolinska Institutet

4. Stockholm 171 65

5. Sweden

6. Department of Biochemistry and Biophysics

7. Stockholm University

8. Stockholm 106 91

9. Department of Materials and Environmental Chemistry

10. Department of Biosciences and Nutrition

11. Neo

12. Department of Chemistry – BMC

13. Uppsala University

14. Box 576

15. Uppsala

16. Department of Chemistry

17. University of Oxford

18. South Parks Road

19. Oxford OX1 3QZ

20. UK

21. Biomolecular Interaction Centre and School of Physical and Chemical Sciences

22. University of Canterbury

23. Christchurch 8140

24. New Zealand

Abstract

Although native mass spectrometry is widely applied to monitor chemical or thermal protein denaturation, it is not clear to what extent it can inform about alkali-induced unfolding.

Funder

Stiftelsen för Strategisk Forskning

Novo Nordisk Fonden

Stiftelsen Olle Engkvist Byggmästare

Science for Life Laboratory

Cancerfonden

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D0CC08135C

Reference23 articles.

1. The diverse and expanding role of mass spectrometry in structural and molecular biology

2. Do Charge State Signatures Guarantee Protein Conformations?

3. The relationships between the isoelectric point and: length of proteins, taxonomy and ecology of organisms

4. Unfolding of proteins monitored by electrospray ionization mass spectrometry: a comparison of positive and negative ion modes

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