Label-free cell phenotypic study of FFA4 and FFA1 and discovery of novel agonists of FFA4 from natural products-Reference-Cited by-同舟云学术

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Label-free cell phenotypic study of FFA4 and FFA1 and discovery of novel agonists of FFA4 from natural products

Published:2019 Issue:26 Volume:9 Page:15073-15083
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Xu Fangfang¹²³⁴⁵,Zhou Han¹²³⁴⁵,Liu Xiumei¹²³⁴⁵,Zhang Xiuli¹²³⁴⁵^ORCID,Wang Zhiwei⁶⁷⁵,Hou Tao¹²³⁴⁵,Wang Jixia¹²³⁴⁵,Qu Lala¹²³⁴⁵,Zhang Pengyu⁸⁹¹⁰⁵,Piao Hailong¹²³⁴⁵,Liang Xinmiao¹²³⁴⁵^ORCID

Affiliation:

1. Key Lab of Separation Science for Analytical Chemistry

2. Dalian Institute of Chemical Physics

3. Chinese Academy of Sciences

4. Dalian

5. China

6. DICP-CMC Innovation Institute of Medicine

7. Taizhou 225300

8. Liaoning Provincial Core Lab of Medical Molecular Biology

9. Dalian Medical University

10. Dalian 116044

Abstract

Pharmacological studies of the FFA4 and FFA1 and discovery of three novel agonists was conducted using a label-free DMR assay.

Funder

Dalian Institute of Chemical Physics

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA02142F

Reference43 articles.

1. Complex Pharmacology of Free Fatty Acid Receptors

2. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

3. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

4. DHA supplementation prevent the progression of NASH via GPR120 signaling

5. Discovery of a Potent and Selective GPR120 Agonist

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3. Ursodesoxycholic acid is an FFA4 agonist and reduces hepatic steatosis via FFA4 signaling;European Journal of Pharmacology;2022-02

4. Identification and target-pathway deconvolution of FFA4 agonists with anti-diabetic activity from Arnebia euchroma (Royle) Johnst;Pharmacological Research;2021-01

5. Synthesis and evaluation of 3-(4-(phenoxymethyl)phenyl)propanoic acid and N-phenylbenzenesulfonamide derivatives as FFA4 agonists;Bioorganic & Medicinal Chemistry Letters;2020-12

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