Discovery of a Potent and Selective GPR120 Agonist-Reference-Cited by-同舟云学术

Discovery of a Potent and Selective GPR120 Agonist

Published:2012-05-02 Issue:9 Volume:55 Page:4511-4515
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shimpukade Bharat¹,Hudson Brian D.²,Hovgaard Christine Kiel¹,Milligan Graeme²,Ulven Trond¹

Affiliation:

1. Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark

2. Molecular Pharmacology Group, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, Scotland, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300215x

Reference21 articles.

1. Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review

2. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

3. GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

4. Distribution and regulation of protein expression of the free fatty acid receptor GPR120

5. Targeting GPR120 and other fatty acid-sensing GPCRs ameliorates insulin resistance and inflammatory diseases

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