Structural insights and influence of V599 mutations on the overall dynamics of BRAF protein against its kinase domains-Reference-Cited by-同舟云学术

Structural insights and influence of V599 mutations on the overall dynamics of BRAF protein against its kinase domains

Published:2018 Issue:10 Volume:10 Page:646-657
ISSN:1757-9694
Container-title:Integrative Biology
language:en
Short-container-title:Integr. Biol.

Author:

Mayank Mayank¹²³,Kaur Navneet¹⁴³,Singh Narinder¹²³^ORCID

Affiliation:

1. Department of Chemistry

2. Indian Institute of Technology Ropar

3. India

4. Punjab University Chandigarh

Abstract

Mutations in the 599th residues provide multiple BRAF forms. Although the 599th residue is situated far from the BRAF ATP binding cavity, it is found to be critical in controlling all the vital functions of its kinase domain.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

Link

http://pubs.rsc.org/en/content/articlepdf/2018/IB/C8IB00095F

Reference52 articles.

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