Anticancer SAR establishment and α/β-tubulin isoform specific targeting: a detailed insight of the anticancer potential of 4<i>H</i>-chromene derivatives-Reference-Cited by-同舟云学术

Anticancer SAR establishment and α/β-tubulin isoform specific targeting: a detailed insight of the anticancer potential of 4H-chromene derivatives

Published:2023 Issue:18 Volume:47 Page:8589-8601
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Mayank ¹²^ORCID,Singh Ashutosh³,Saumya Kumar Udit³,Joshi Mayank⁴^ORCID,Kaur Navneet⁵^ORCID,Garg Neha³⁶^ORCID,Singh Narinder¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology Ropar, Punjab 140001, India

2. University College of Pharmacy, Guru Kashi University, Talwandi Sabo, India

3. School of Basic Sciences, Indian Institute of Technology Mandi, Himachal Pradesh 175005, India

4. M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133207, India

5. Department of Chemistry, Punjab University, Chandigarh, 160014, India

6. Department of Medicinal Chemistry, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh-221005, India

Abstract

The anticancer activity of chromene derivatives was explored. MNC-1 showed the best anticancer potential and is expected to deliver the best activity against cancer cells with β1 and/or β8 over-expression.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D2NJ04822A

Reference24 articles.

1. Therapeutic journery of nitrogen mustard as alkylating anticancer agents: Historic to future perspectives

2. Target-based anticancer indole derivatives and insight into structure‒activity relationship: A mechanistic review update (2018–2021)

3. Insights into microtubule nucleation from the crystal structure of human γ-tubulin

4. Computational Modeling and Cryo Electron Tomography Reveal a New Mechanism for Microtubule Assembly and Dynamics

5. Discovery of Novel Tubulin Inhibitors via Structure-Based Hierarchical Virtual Screening

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