A convenient transformation of alkynes to α-hydroxy-α-CF3-γ-ketoester derivatives via H3PO4-catalyzed tandem hydration and aldol condensation-Reference-Cited by-同舟云学术

A convenient transformation of alkynes to α-hydroxy-α-CF₃-γ-ketoester derivatives via H₃PO₄-catalyzed tandem hydration and aldol condensation

Published:2022 Issue:14 Volume:24 Page:5547-5552
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Wang Jiali¹,Yao Jun¹,Jia Chunqi¹,Hu Dandan¹,Chen Yun-Hua²,Song Jinyu¹,Zhang Jun-Qi¹,Ren Hongjun¹³^ORCID

Affiliation:

1. Advanced Research Institute and Department of Chemistry, Taizhou University, Jiaojiang 318000, Zhejiang, P. R. China

2. Chemical Pharmaceutical Research Institute, Taizhou Vocational & Technical College, Taizhou 318000, P. R. China

3. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453000, P.R. China

Abstract

A robust metal-free catalytic strategy for the rapid construction of the valuable α-hydroxy-α-CF3-γ-ketoester skeleton with cheap and easily available stock chemicals (alkynes and trifluoropyruvate) as the starting material is described.

Funder

Henan Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/GC/D2GC01199A

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