Inhibition of respiratory Complex I by copper(ii)-bis(thiosemicarbazonato) complexes
Author:
Affiliation:
1. School of Chemistry and Molecular Biosciences
2. The University of Queensland
3. St Lucia, Australia
4. School of Chemistry and Bio21 Molecular Science and Biotechnology Institute
5. The University of Melbourne
6. Parkville, Australia
Abstract
The family of CuII-bis(thiosemicarbazone) complexes inhibits Complex I of the respiratory chain without apparent release of bioavailable Cu ions.
Funder
National Health and Medical Research Council
Publisher
Oxford University Press (OUP)
Subject
Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)
Link
http://pubs.rsc.org/en/content/articlepdf/2014/MT/C4MT00226A
Reference37 articles.
1. Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals
2. Antimicrobial effects of copper(ii) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action
3. Copper-Boosting Compounds: a Novel Concept for Antimycobacterial Drug Discovery
4. Copper Complexation Screen Reveals Compounds with Potent Antibiotic Properties against Methicillin-Resistant Staphylococcus aureus
5. Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships
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