Antimicrobial effects of copper(ii) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action-Reference-Cited by-同舟云学术

Antimicrobial effects of copper(ii) bis(thiosemicarbazonato) complexes provide new insight into their biochemical mode of action

Published:2014 Issue:4 Volume:6 Page:854-863
ISSN:1756-5901
Container-title:Metallomics
language:en
Short-container-title:Metallomics

Author:

Djoko Karrera Y.¹²³,Paterson Brett M.⁴⁵⁶,Donnelly Paul S.⁴⁵⁶,McEwan Alastair G.¹²³

Affiliation:

1. School of Chemistry and Molecular Biosciences and Australian Centre for Infectious Diseases Research

2. University of Queensland

3. St Lucia, Australia

4. School of Chemistry and Bio21 Molecular Science and Biotechnology Institute

5. University of Melbourne

6. Parkville, Australia

Abstract

The copper(ii) complexes of bis-thiosemicarbazones such as Cu(atsm) and Cu(gtsm) display potent antimicrobial properties via inhibition of respiratory dehydrogenases.

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MT/C3MT00348E

Reference37 articles.

1. Assessment of tumor hypoxia by 62Cu-ATSM PET/CT as a predictor of response in head and neck cancer: a pilot study

2. The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

3. Increasing Cu bioavailability inhibits A oligomers and tau phosphorylation

4. Cell cycle arrest in cultured neuroblastoma cells exposed to a bis(thiosemicarbazonato) metal complex

5. Increasing Intracellular Bioavailable Copper Selectively Targets Prostate Cancer Cells

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