Examining the role of phosphorylation of p19INK4d in its stability and ubiquitination using chemical protein synthesis-Reference-Cited by-同舟云学术

Examining the role of phosphorylation of p19INK4d in its stability and ubiquitination using chemical protein synthesis

Published:2020 Issue:21 Volume:11 Page:5526-5531
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Msallam Muna¹²³⁴,Sun Hao¹²³⁴,Meledin Roman¹²³⁴,Franz Pauline¹²³⁴,Brik Ashraf¹²³⁴^ORCID

Affiliation:

1. Schulich Faculty of Chemistry

2. Technion-Israel Institute of Technology

3. Hailfa 32000

4. Israel

Abstract

This study describes the chemical synthesis of unmodified and phosphorylated p19^INK4d that were characterized by circular dichroism and biochemical methods to examine the effect of phosphorylation on the thermal stability and ubiquitination.

Funder

Horizon 2020 Framework Programme

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC06300E

Reference29 articles.

1. Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4

2. Structure of human cyclin-dependent kinase inhibitor p19INK4d: comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16INK4a

3. INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions

4. The INK4 family of cell cycle inhibitors in cancer

5. Structure of the cyclin-dependent kinase inhibitor p19Ink4d

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