Electrochemical tandem trifluoromethylation of allylamines/formal (3 + 2)-cycloaddition for the rapid access to CF3-containing imidazolines and oxazolidines-Reference-Cited by-同舟云学术

Electrochemical tandem trifluoromethylation of allylamines/formal (3 + 2)-cycloaddition for the rapid access to CF3-containing imidazolines and oxazolidines

Published:2021 Issue:2 Volume:8 Page:288-296
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Claraz Aurélie¹²³⁴⁵^ORCID,Djian Aurélie¹²³⁴⁵,Masson Géraldine¹²³⁴⁵^ORCID

Affiliation:

1. Institut de Chimie des Substances Naturelles

2. Université Paris Saclay

3. CNRS

4. UPR2301

5. 91198 Gif-sur-Yvette cedex

Abstract

A straightforward and environmentally friendly synthesis of CF₃-containing imidazolines and oxazolidines has been developed through an electrochemical three-component reaction among allylamines, the Langlois reagent, and nitrile or carbonyl compounds.

Funder

Centre National de la Recherche Scientifique

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/QO/D0QO01307B

Reference130 articles.

1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

2. Inhibition of the Human Proteasome by Imidazoline Scaffolds

3. Catalytic, enantioselective synthesis of stilbene cis-diamines: A concise preparation of (−)-Nutlin-3, a potent p53/MDM2 inhibitor