Discovery of a series of 2-phenylnaphthalenes as firefly luciferase inhibitors-Reference-Cited by-同舟云学术

Discovery of a series of 2-phenylnaphthalenes as firefly luciferase inhibitors

Published:2015 Issue:78 Volume:5 Page:63450-63457
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bai Haixiu¹²³⁴⁵,Chen Wang⁶²³⁴⁵,Wu Wenxiao¹²³⁴⁵,Ma Zhao¹²³⁴⁵,Zhang Huateng¹²³⁴⁵,Jiang Tianyu¹²³⁴⁵,Zhang Tianchao¹²³⁴⁵,Zhou Yubin⁷⁸⁹¹⁰¹¹,Du Lupei¹²³⁴⁵,Shen Yuemao⁶²³⁴⁵,Li Minyong¹²³⁴⁵^ORCID

Affiliation:

1. Department of Medicinal Chemistry

2. Key Laboratory of Chemical Biology (MOE)

3. School of Pharmacy

4. Shandong University

5. Jinan

6. Department of Natural Products

7. Center for Translational Cancer Research

8. Institute of Biosciences & Technology

9. Texas A&M University Health Science Center

10. Houston

11. USA

Abstract

A series of 2-phenylnaphthalenes as firefly luciferase inhibitors are reported. The most potent compound 5 showed good systemic inhibition in transgenic mice. Kinetic assay indicated 5 is competitive for aminoluciferin and noncompetitive for ATP.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA12886B

Reference43 articles.

1. Cage the firefly luciferin! – a strategy for developing bioluminescent probes

2. Kinetics of inhibition of firefly luciferase by oxyluciferin and dehydroluciferyl-adenylate

3. Coenzyme A affects firefly luciferase luminescence because it acts as a substrate and not as an allosteric effector

4. Kinetics of inhibition of firefly luciferase by dehydroluciferyl-coenzyme A, dehydroluciferin and l-luciferin

5. Firefly Luciferase Produces Hydrogen Peroxide as a Coproduct in Dehydroluciferyl Adenylate Formation

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