Construction of redox/pH dual stimuli-responsive PEGylated polymeric micelles for intracellular doxorubicin delivery in liver cancer

Author:

Yang Hong Yu12345,Jang Moon-Sun678910,Gao Guang Hui1112131415,Lee Jung Hee678910,Lee Doo Sung12345

Affiliation:

1. Theranostic Macromolecules Research Center

2. School of Chemical Engineering

3. Sungkyunkwan University

4. Suwon 440-746

5. Republic of Korea

6. Department of Radiology

7. Samsung Medical Center

8. Sungkyunkwan University School of Medicine and Center for Molecular and Cellular Imaging

9. Samsung Biomedical Research Institute

10. Seoul 135-710

11. Engineering Research Center of Synthetic Resin and Special Fiber

12. Ministry of Education

13. Changchun University of Technology

14. Changchun 130012

15. China

Abstract

A schematic of the complete process of DOX-loaded mPEG-SS-PNLG micelles uptake into tumor cells and intracellular release of DOX; size distribution of mPEG-SS-PNLG (90%) micelles and in vivo antitumor efficacy.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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