A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring-Reference-Cited by-同舟云学术

A minimal structural variation can overcome tumour resistance of oxaliplatin: the case of 4,5-dehydrogenation of the cyclohexane ring

Published:2019 Issue:56 Volume:9 Page:32448-32452
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Papadia Paride¹²³⁴⁵^ORCID,Gandin Valentina⁶⁷⁸⁴,Barbanente Alessandra⁵⁹⁴¹⁰¹¹,Ruello Alessandro G.⁵⁹⁴¹⁰¹¹,Marzano Cristina⁶⁷⁸⁴,Micoli Katia⁵⁹⁴¹⁰¹¹,Hoeschele James D.¹²¹³¹⁴¹⁵,Natile Giovanni⁵⁹⁴¹⁰¹¹,Margiotta Nicola⁵⁹⁴¹⁰¹¹^ORCID

Affiliation:

1. Department of Biological and Environmental Sciences and Technologies (DiSTeBA)

2. University of Salento

3. 73100 Lecce

4. Italy

5. CIRCMSB, Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici

6. Dipartimento di Scienze del Farmaco

7. Università di Padova

8. Padova

9. 70121 Bari

10. Dipartimento di Chimica

11. Università degli Studi di Bari Aldo Moro

12. Department of Chemistry

13. Eastern Michigan University

14. 48197 Ypsilanti

15. USA

Abstract

A new family of anticancer compounds has been derived from oxaliplatin by inserting a double-bond between carbons 4 and 5 of the 1,2-diaminocyclohexane ring.

Funder

Università del Salento

Università degli Studi di Padova

Ministero dell'Istruzione, dell'Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/RA/C9RA07760J

Reference24 articles.

1. Oxaliplatin