Pt(<scp>ii</scp>) complex containing the 1R,2R enantiomer of trans-1,2-diamino-4-cyclohexene ligand effectively and selectively inhibits the viability of aggressive pancreatic adenocarcinoma cells and alters their lipid metabolism-Reference-Cited by-同舟云学术

Pt(ii) complex containing the 1R,2R enantiomer of trans-1,2-diamino-4-cyclohexene ligand effectively and selectively inhibits the viability of aggressive pancreatic adenocarcinoma cells and alters their lipid metabolism

Published:2022 Issue:13 Volume:9 Page:3295-3305
ISSN:2052-1553
Container-title:Inorganic Chemistry Frontiers
language:en
Short-container-title:Inorg. Chem. Front.

Author:

Novohradsky Vojtech¹^ORCID,Markova Lenka¹^ORCID,Kostrhunova Hana¹^ORCID,Svitelova Marie¹,Kasparkova Jana¹²^ORCID,Barbanente Alessandra³,Papadia Paride⁴^ORCID,Margiotta Nicola³^ORCID,Hoeschele James D.⁵,Brabec Viktor¹^ORCID

Affiliation:

1. Czech Academy of Sciences, Institute of Biophysics, Kralovopolska 135, CZ-61265 Brno, Czech Republic

2. Department of Biophysics, Faculty of Science, Palacky University in Olomouc, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic

3. Dipartimento di Chimica, Università degli Studi di Bari Aldo Moro, Via Orabona, 4, I-70125 Bari, Italy

4. Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, 73100 Lecce, Italy

5. Department of Chemistry, Eastern Michigan University, Ypsilanti, MI 48197, USA

Abstract

New compounds structurally derived from oxaliplatin exhibit high potency in malignant pancreatic adenocarcinoma cells. Their mechanism of antiproliferative action in pancreatic cancer cells involves inhibition of de novo lipid synthesis.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QI/D2QI00778A

Reference42 articles.

1. Pancreatic adenocarcinoma

2. Metabolism addiction in pancreatic cancer

3. Lipid metabolism in cancer cells under metabolic stress

4. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

5. De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer

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