Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system-Reference-Cited by-同舟云学术

Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system

Published:2018 Issue:48 Volume:16 Page:9373-9376
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Pei Zeng-Fei¹²³⁴⁵,Yang Min-Jie¹²³⁴⁵,Li Lei⁶⁷⁸⁵⁹,Jian Xiao-Hong¹²³⁴⁵,Yin Yue¹²³⁴⁵,Li Dehai¹⁰¹¹¹²¹³¹⁴^ORCID,Pan Hai-Xue¹²³⁴⁵,Lu Yinhua¹⁵¹⁶⁹¹⁷,Jiang Weihong⁶⁷⁸⁵⁹,Tang Gong-Li¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Bioorganic and Natural Products Chemistry

2. Center for Excellence in Molecular Synthesis

3. Shanghai Institute of Organic Chemistry

4. University of Chinese Academy of Sciences

5. Chinese Academy of Sciences

6. Key Laboratory of Synthetic Biology

7. Institute of Plant Physiology and Ecology

8. Shanghai Institutes for Biological Sciences

9. Shanghai

10. Key Laboratory of Marine Drugs

11. Ministry of Education of China

12. School of Medicine and Pharmacy

13. Ocean University of China

14. Qingdao

15. School of Life and Environmental Sciences

16. Shanghai Normal University

17. China

Abstract

Aurantizolicin and new compound 3 with improved bioactivity were generated highly effectively by heterologous expression of an engineered YM-216391 biosynthetic gene cluster.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02665C

Reference17 articles.

1. YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis

2. YM-216391, a Novel Cytotoxic Cyclic Peptide from Streptomyces nobilis