Mechercharmycins A and B, Cytotoxic Substances from Marine-derived Thermoactinomyces sp. YM3-251

Author:

Kanoh Kaneo,Matsuo Yoshihide,Adachi Kyoko,Imagawa Hiroshi,Nishizawa Mugio,Shizuri Yoshikazu

Publisher

Springer Science and Business Media LLC

Subject

Drug Discovery,Pharmacology

Reference8 articles.

1. Blunt JW, Copp BR, Munro MHG, Northcote PT, Prinsep MR . Marine natural products. Nat Prod Rep 21: 1–49 ( 2004)

2. Compound 1 was reported as a cytotoxic substance in a patent during the preparation of this manuscript. Romero P, Malet L, Canedo LM, Cuevas C, Fernando RJ. New cytotoxic depsipeptides. WO 2005/000880 A2, January 6, 2005

3. The strain producing 1 and 2, The, has been identified as Thermoactinomyces sp. by taxonomic studies, including a 16S rDNA sequence analysis. The strain has been deposited in the NITE Patent Microorganisms Depositary (NPMD) in Japan as NITE P-2.

4. The B2 medium (1 liter) contained 5 g of peptone, 1 g of yeast extract, 1.1 g of iron (III) citrate n-hydrate, 750 ml of filtered natural sea water, and 250 ml of distilled water (pH 7.6, before sterilization).

5. Shin-ya K, Wierzba K, Matsuo K, Ohtani T, Yamada Y, Furihata K, Hayakawa Y, Seto H . Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus. J Am Chem Soc 123: 1262–1263 ( 2001)

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