Bacterial Proteins and Peptides as Potential Anticancer Agents: A Novel Search for Protein-based Therapeutics-Reference-Cited by-同舟云学术

Bacterial Proteins and Peptides as Potential Anticancer Agents: A Novel Search for Protein-based Therapeutics

Published:2024-02-07 Issue: Volume:31 Page:
ISSN:0929-8673
Container-title:Current Medicinal Chemistry
language:en
Short-container-title:CMC

Author:

Pyla Mahitha¹,Kankipati Sanjana¹,Sumithra B.¹,Mishra Piyush Kumar²,Mishra Bishwambhar¹,Mandal Sanjeeb Kumar¹,Panda Jibanjyoti³,Chopra Hitesh⁴,Satya Kumar Avula⁵,Salah Mohamed⁶,Mohanta Yugal Kishore³,Kamal Mohammad Amjad⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Department of Biotechnology, Chaitanya Bharathi Institute of Technology (CBIT), Gardipe, Hyderabad - 500075, Telangana, India

2. Department of Botany, B. N. College, Dhubri-783324, Assam, India

3. Nanobiotechnology and Translational Knowledge Laboratory, Department of Applied Biology, School of Biological Sciences, University of Science and Technology Meghalaya (USTM), Techno City, 9th Mile, Baridua-- 793101, Ri-Bhoi, Meghalaya, India

4. Department of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai-602105, Tamil Nadu, India

5. Natural and Medical Sciences Research Centre, University of Nizwa, Nizwa, 616, Oman

6. Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, Zagazig44519, Egypt

7. King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia

8. Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, China

9. Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Bangladesh

10. Enzymoics, 7 Peterlee place, Hebersham, NSW 2770; Novel Global Community Educational Foundation, Australia

Abstract

Tumor diseases remain among the world's primary causes of death despite substantial advances in cancer diagnosis and treatment. The adverse chemotherapy problems and sensitivity towards drugs for some cancer types are among the most promising challenges in modern treatment. Finding new anti-cancer agents and drugs is, therefore, essential. A significant class of biologically active substances and prospective medications against cancer is comprised of bacterial proteins and peptides. Among these bacterial peptides, some of them, such as anti-cancer antibiotics and many toxins like diphtheria are widely being used in the treatment of cancer. In contrast, the remaining bacterial peptides are either in clinical trials or under research in vitro studies. This study includes the most recent information on the characteristics and mechanism of action of the bacterial peptides that have anti-cancer activities, some of which are now being employed in cancer therapy while some are still undergoing research.

Publisher

Bentham Science Publishers Ltd.