Semi-syntheses and interrogation of indole-substituted <i>Aspidosperma</i> terpenoid alkaloids-Reference-Cited by-同舟云学术

Semi-syntheses and interrogation of indole-substituted Aspidosperma terpenoid alkaloids

Published:2022 Issue:19 Volume:20 Page:3988-3997
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Kang Jinfeng¹,Lewis Todd R.¹,Gardner Alex¹,Andrade Rodrigo B.¹,Wang Rongsheng E.¹^ORCID

Affiliation:

1. Department of Chemistry, Temple University, 1901 N. 13th Street, Philadelphia, PA, 19122, USA

Abstract

Aspidosperma terpenoid alkaloids can be quickly prepared using semisynthesis from naturally sourced tabersonine, featuring multiple oxygen-based substituents on the indole ring such as hydroxy and methoxy groups for cancer-targeted SAR studies.

Funder

National Institute of General Medical Sciences

Research Corporation for Science Advancement

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00610C

Reference31 articles.

1. Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in Catharanthus roseus

2. Cytotoxic Indole Alkaloids from Melodinus tenuicaudatus

3. Domino Michael/Mannich/N-Alkylation Route to the Tetrahydrocarbazole Framework of Aspidosperma Alkaloids: Concise Total Syntheses of (−)-Aspidospermidine, (−)-Tabersonine, and (−)-Vincadifformine

4. Vinblastine and Griseofulvin Reversibly Disrupt the Living Mitotic Spindle

5. Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead

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