Inhibition of mitochondrial metabolism by (−)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells-Reference-Cited by-同舟云学术

Inhibition of mitochondrial metabolism by (−)-jerantinine A: synthesis and biological studies in triple-negative breast cancer cells

Published:2023 Issue:4 Volume:14 Page:710-714
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Gialelis Timothy L.¹^ORCID,Wang Zifei²^ORCID,Homer Joshua A.²^ORCID,Yang Wen-Hsuan²^ORCID,Chung Taemoon²^ORCID,Hu Qingting²³^ORCID,Smedley Christopher J.¹^ORCID,Pawar Nitin J.²^ORCID,Upadhyay Nitinkumar S.²^ORCID,Tuveson David A.²^ORCID,Lyons Scott K.²^ORCID,Lukey Michael J.²^ORCID,Moses John E.²^ORCID

Affiliation:

1. La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia

2. Cancer Center, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA

3. Graduate Program in Genetics, Stony Brook University, Stony Brook, NY 11794, USA

Abstract

We report an improved 4-step semisynthesis of (−)-jerantinine A and (−)-melodinine P from (−)-tabersonine, qualify their potency against TNBC cells and confirm they induce oxidative stress. JA also acts as a potent inhibitor of nucleotide metabolism.

Funder

METAvivor

Elsa U. Pardee Foundation

La Trobe University

National Cancer Institute

Cold Spring Harbor Laboratory

F. M. Kirby Foundation

Starr Foundation

U.S. Department of Defense

Publisher

Royal Society of Chemistry (RSC)

Subject