Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype-Reference-Cited by-同舟云学术

Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype

Published:2021 Issue:8 Volume:12 Page:1391-1401
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Brooke Daniel P.¹,McGee Leah M. C.¹,Giordani Federica²^ORCID,Cross Jasmine M.¹,Khalaf Abedawn I.¹^ORCID,Irving Craig¹,Gillingwater Kirsten³⁴,Shaw Craig D.⁵,Carter Katharine C.⁵,Barrett Michael P.²,Suckling Colin J.¹,Scott Fraser J.¹^ORCID

Affiliation:

1. WestCHEM Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK

2. Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation and Glasgow Polyomics, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

3. Parasite Chemotherapy Unit, Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland

4. University of Basel, Basel, Switzerland

5. Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, UK

Abstract

This paper describes the design and synthesis of Strathclyde minor groove binders (S-MGBs) that have been truncated by the removal of a pyrrole ring in order to mimic the structure of the natural product, disgocidine.

Funder

Carnegie Trust for the Universities of Scotland

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00110H

Reference22 articles.

1. R. R.Tidwell and D. W.Boykin , Dicationic DNA Minor Groove Binders as Antimicrobial Agents, in Small Molecule DNA and RNA Binders , ed. D. Martine , C. Bailly and W. D. Wilson , Wiley-VCH Verlag GmbH & Co. KGaA , London , 2004 , pp. 414–460

2. Dications That Target the DNA Minor Groove: Compound Design and Preparation, DNA Interactions, Cellular Distribution and Biological Activity

3. Antimicrobial Lexitropsins Containing Amide, Amidine, and Alkene Linking Groups

4. Distamycin Analogues with Enhanced Lipophilicity: Synthesis and Antimicrobial Activity

5. MGB Biopharma Home Page (2019), Available at http://www.mgb-biopharma.com (Accessed 9th January, 2019 )

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Strathclyde minor groove binders (S-MGBs) with activity against Acanthamoeba castellanii;Journal of Antimicrobial Chemotherapy;2024-07-09

2. Insights into the Spectrum of Activity and Mechanism of Action of MGB-BP-3;ACS Infectious Diseases;2022-11-29

3. Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification;International Journal of Molecular Sciences;2022-10-07

4. Correction: Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype;RSC Medicinal Chemistry;2021