A new approach toward the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives using fluoroalkyl amino reagent chemistry-Reference-Cited by-同舟云学术

A new approach toward the synthesis of 2,4-bis(fluoroalkyl)-substituted quinoline derivatives using fluoroalkyl amino reagent chemistry

Published:2016 Issue:11 Volume:3 Page:1392-1415
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Aribi Fallia¹²³⁴⁵,Schmitt Etienne¹²³⁴⁵,Panossian Armen¹²³⁴⁵,Vors Jean-Pierre⁶⁷⁸⁴⁵,Pazenok Sergiy⁹¹⁰¹¹⁵⁴,Leroux Frédéric R.¹²³⁴⁵^ORCID

Affiliation:

1. University of Strasbourg

2. UMR CNRS 7509

3. 67087 Strasbourg

4. France

5. Joint laboratory Unistra-CNRS-Bayer (Chemistry of Organofluorine Compounds)

6. Bayer S.A.S.

7. 14 Impasse Pierre Baizet

8. 69263 Lyon Cedex 09

9. Bayer CropScience AG

10. 40789 Monheim

11. Germany

Abstract

The present work describes the unprecedented use of Fluoroalkyl Amino Reagents (FARs) to afford 2,4-bis(fluoroalkyl)-substituted quinoline derivatives in two steps under mild reaction conditions, in good yields and with a very good regioselectivity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/QO/C6QO00319B

Reference68 articles.

1. J. P. Bégué and D.Bonnet-Delpon, Bioorganic and Medicinal Chemistry of Fluorine, John Wiley & Sons, Hoboken, New Jersey, 2008

2. I. Ojima , Fluorine in Medicinal Chemistry and Chemical Biology, Wiley-Blackwell, 2009

3. P. Jeschke , in Modern Methods in Crop Protection Research, ed. P. Jeschke, W. Krämer, U. Schirmer and M. Witschel, Wiley-VCH, Weinheim, Germany, 2012, ch. 4, pp. 73–128

4. The Unique Role of Fluorine in the Design of Active Ingredients for Modern Crop Protection

5. α-Fluorinated Ethers as “Exotic” Entity in Medicinal Chemistry

Cited by 22 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Concise synthesis of 2,4-bis(fluoroalkyl)quinoline derivatives from arylamines;Tetrahedron;2024-08

2. Concise Synthesis of 2,4-Bis(Fluoroalkyl)Quinoline Derivatives from Arylamines;2024

3. Assembly of fluorinated benzodiazepines via Rh(iii)-catalysed [5+2] annulation of N-benzo[d]imidazole indolines with 2,2-difluorovinyl tosylate;New Journal of Chemistry;2023

4. Cyclometalated iridium complexes-catalyzed acceptorless dehydrogenative coupling reaction: construction of quinoline derivatives and evaluation of their antimicrobial activities;Beilstein Journal of Organic Chemistry;2022-10-27

5. Synthesis of 1‐Trifluoromethylated Propargyl Alcohols by Two Successive Reactions of Cyclopentylmagnesium Bromide in a One‐Pot Manner;Asian Journal of Organic Chemistry;2022-01-04