Study of nusinersen metabolites in the cerebrospinal fluid of children with spinal muscular atrophy using ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry-Reference-Cited by-同舟云学术

Study of nusinersen metabolites in the cerebrospinal fluid of children with spinal muscular atrophy using ultra-high-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry

Published:2024 Issue:14 Volume:149 Page:3739-3746
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Studzińska Sylwia¹²^ORCID,Błachowicz Oliwia¹,Bocian Szymon¹^ORCID,Kalisz Oktawia¹^ORCID,Jaworska Aleksandra¹,Szymarek Jakub³,Mazurkiewicz-Bełdzińska Maria³

Affiliation:

1. Chair of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University in Toruń, 7 Gagarin St., 87-100 Toruń, Poland

2. Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University in Toruń, 4 Wilenska St., 87-100 Toruń, Poland

3. Department of Developmental Neurology, Medical University of Gdansk, 7 Dębinki Str., PL-80-952, Gdańsk, Poland

Abstract

This study aimed to analyze nusinersen metabolites in cerebrospinal fluid samples using ion-pair reversed-phase ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/AN/D4AN00436A

Reference22 articles.

1. Nusinersen: First Global Approval

2. US Food and Drug Administration , 2016 , 2016 Novel Drugs Summary. https://Www.Fda.Gov/News-Events/Press-Announcements/Fda-Approves-First-Drug-Spinal-Muscular-Atrophy

3. European Medicines Agency , 2017 , Spinraza. https://www.Ema.Europa.Eu/En/Homepage

4. Nusinersen Induces Disease-Severity-Specific Neurometabolic Effects in Spinal Muscular Atrophy

5. Molecular Biomarkers for the Diagnosis, Prognosis, and Pharmacodynamics of Spinal Muscular Atrophy