A UPLC-MS/MS method for simultaneous quantification of pairs of oleanene- and ursane-type triterpenoid saponins and their major metabolites in mice plasma and its application to a comparative pharmacokinetic study

Author:

Zhao Wenwen12345,Liu Zongyang12345,Guo Weiwei12345,Luo Kui6345,Yang Jie7895,Gao Wei12345,Wu Xia12345,Chen Xiaoqing12345ORCID

Affiliation:

1. School of Traditional Chinese Medicine

2. Beijing Key Lab of TCM Collateral Disease Theory Research

3. Capital Medical University

4. Beijing 100069

5. China

6. Core Facilities Center

7. Department of Chinese Medicines Analysis

8. China Pharmaceutical University

9. Nanjing 210009

Abstract

Pharmacokinetic study of pairs of oleanene- and ursane-type triterpenoid saponins and their major metabolites in control & NAFLD mice.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference27 articles.

1. Department of Health of Guangxi Zhuang Minority Autonomous Region , Chinese Medicinal Materials Standard of Guangxi (1990 ed.) , Guangxi Science and Technology Press , Nanning , 1992

2. Preventive Effects of Flavonoid Extracts from Ilex hainanensisMerr. on Rats with Hepatic Steatosis Induced by a High-Fat Diet

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