Elucidating bis-pyrimidines as new and efficient mushroom tyrosinase inhibitors: synthesis, SAR, kinetics and computational studies-Reference-Cited by-同舟云学术

Elucidating bis-pyrimidines as new and efficient mushroom tyrosinase inhibitors: synthesis, SAR, kinetics and computational studies

Published:2024 Issue:31 Volume:14 Page:22769-22780
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Afzal Manazza¹,Mehmood Rabia¹,Mughal Ehsan Ullah²^ORCID,Naeem Nafeesa²^ORCID,Ashraf Zaman³,Nazir Yasir⁴,Shalaby Fatma Mohsen⁵,El-Sayed Abd El Hady Amal⁶,Sadiq Amina¹

Affiliation:

1. Department of Chemistry, Govt College Women University, Sialkot-51300, Pakistan

2. Department of Chemistry, University of Gujrat, Gujrat-50700, Pakistan

3. Department of Chemistry, Rawalpindi Women University, Rawalpindi-46300, Pakistan

4. Department of Chemistry, University of Sialkot, Sialkot-51300, Pakistan

5. King Khalid University, Faculty of Sciences, Biology Department, Abha, Kingdom of Saudi Arabia

6. Department of Biology, Faculty of Science, Majmaah University, Al Majma'ah 15341, Kingdom of Saudi Arabia

Abstract

In this study, a series of novel bis-pyrimidine derivatives (1P–8P) were designed, synthesized, characterized, and investigated for their in vitro inhibitory activity against mushroom tyrosinase.

Funder

King Khalid University

Higher Education Commission, Pakistan

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA04652H

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