Natural allosteric modulators and their biological targets: molecular signatures and mechanisms-Reference-Cited by-同舟云学术

Natural allosteric modulators and their biological targets: molecular signatures and mechanisms

Published:2020 Issue:4 Volume:37 Page:488-514
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Bruder Marjorie¹²³⁴^ORCID,Polo Gina¹²³⁴^ORCID,Trivella Daniela B. B.¹²³⁴^ORCID

Affiliation:

1. Brazilian Biosciences National Laboratory (LNBio)

2. National Centre for Research in Energy and Materials (CNPEM)

3. 13083-970 Campinas

4. Brazil

Abstract

Natural allosteric modulators reported over the last decade are reviewed on a chemical and mechanistic basis, emphasising the importance of natural products as probes for future allosteric drugs.

Funder

Instituto Serrapilheira

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NP/C9NP00064J

Reference235 articles.

1. The concept of allosteric modulation: an overview

2. Allosteric modulation as a unifying mechanism for receptor function and regulation

3. Allosteric Modulator Discovery: From Serendipity to Structure-Based Design

4. Chemical, Target, and Bioactive Properties of Allosteric Modulation

5. Structural and Energetic Basis of Allostery

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