Cholestatic liver injury model of bile duct ligation and the protection of Huang-Lian-Jie-Du decoction by NMR metabolomic profiling-Reference-Cited by-同舟云学术

Cholestatic liver injury model of bile duct ligation and the protection of Huang-Lian-Jie-Du decoction by NMR metabolomic profiling

Published:2015 Issue:81 Volume:5 Page:66200-66211
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Wei Dandan¹²³⁴⁵,Liao Shanting¹²³⁴⁵,Wang Junsong⁶⁷⁸⁵,Yang Minghua¹²³⁴⁵,Kong Lingyi¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Natural Medicines

2. Department of Natural Medicinal Chemistry

3. China Pharmaceutical University

4. Nanjing 210009

5. PR China

6. Center for Molecular Metabolism

7. Nanjing University of Science & Technology

8. Nanjing 210094

Abstract

Bile duct ligation (BDL) induced cholestasis in rats and the treatment effects of Huang-Lian-Jie-Du decoction (HLJDD) were investigated by NMR-based metabolomics approach: biphasic feature of BDL model and bilateral adjustment of HLJDD were found.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA12224D

Reference49 articles.

1. Chronic cholestatic liver diseases: Clues from histopathology for pathogenesis

2. Trolox mitigates fibrosis in a bile duct ligation model

3. Cholestasis induced antinociception and decreased gene expression of MOR1 in rat brain

4. The crucial role of bile acids in the entry of porcine enteric calicivirus

5. The effect of ursodeoxycholic acid on oxidative stress level and DNase activity in rat liver after bile duct ligation

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