Metal-free hypervalent iodine-promoted tandem carbonyl migration and unactivated C(Ph)–C(Alkyl) bond cleavage for quinolone scaffold synthesis-Reference-Cited by-同舟云学术

Metal-free hypervalent iodine-promoted tandem carbonyl migration and unactivated C(Ph)–C(Alkyl) bond cleavage for quinolone scaffold synthesis

Published:2022 Issue:60 Volume:58 Page:8340-8343
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Song Li-Rui¹²,Li He²,Wang Shen-Feng²,Lin Jian-Ping²,Huang Bin¹^ORCID,Long Ya-Qiu¹^ORCID

Affiliation:

1. School of Pharmaceutic Sciences, Soochow University, Suzhou, 215123, China

2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, China

Abstract

An unprecedented metal-free unactivated C(Ph)–C(alkyl) bond cleavage triggered by a tandem radical 5-ipso trig cyclization and 1,2-carbonyl migration to synthesize pharmaceutically important 4-quinolone scaffolds has been developed.

Funder

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC02245A

Reference60 articles.

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5. Transition metal-catalyzed carbon–carbon bond activation

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