Gambogic acid suppresses the pentose phosphate pathway by covalently inhibiting 6PGD protein in cancer cells-Reference-Cited by-同舟云学术

Gambogic acid suppresses the pentose phosphate pathway by covalently inhibiting 6PGD protein in cancer cells

Published:2022 Issue:64 Volume:58 Page:9030-9033
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhu Yinhua¹,Zhang Ying¹,Zhang Qianyu²,Ma Ang¹,Zhang Ying¹,Wang Chen¹,Gao Peng¹,Guo Qiuyan¹,Xia Fei¹,Tang Huan¹,Xu Chengchao¹,Wang Jigang¹^ORCID

Affiliation:

1. Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China

2. Pharmaceutical College, Henan University, Kaifeng, 475004, China

Abstract

Here, we report for the first time the anticancer mechanism of gambogic acid, which covalently inhibits the key rate-limiting enzyme 6PGD in the pentose phosphate pathway, thereby effectively suppressing the metabolic process of cancer cells.

Funder

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC03069A

Reference24 articles.

1. Therapeutic potential of gambogic acid, a caged xanthone, to target cancer

2. A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid

3. Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase

4. Gambogic Acid Deactivates Cytosolic and Mitochondrial Thioredoxins by Covalent Binding to the Functional Domain

5. Gambogic Acid, a Natural Product Inhibitor of Hsp90

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