Photoredox-mediated hydroalkylation and hydroarylation of functionalized olefins for DNA-encoded library synthesis-Reference-Cited by-同舟云学术

Photoredox-mediated hydroalkylation and hydroarylation of functionalized olefins for DNA-encoded library synthesis

Published:2021 Issue:36 Volume:12 Page:12036-12045
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Badir Shorouk O.¹^ORCID,Lipp Alexander¹,Krumb Matthias¹^ORCID,Cabrera-Afonso María Jesús¹^ORCID,Kammer Lisa Marie¹,Wu Victoria E.²,Huang Minxue²,Csakai Adam²,Marcaurelle Lisa A.²,Molander Gary A.¹^ORCID

Affiliation:

1. Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA

2. Encoded Library Technologies/NCE Molecular Discovery, R&D Medicinal Science and Technology, GlaxoSmithKline, 200 Cambridge Park Drive, Cambridge, MA 02140, USA

Abstract

DNA-encoded library (DEL) technology facilitates the rapid identification of therapeutic candidates in pharmaceutical settings. Herein, the development of photoredox-mediated hydrocarbofunctionalization protocols of olefins is described.

Funder

Deutsche Forschungsgemeinschaft

Bristol-Myers Squibb

National Institute of General Medical Sciences

Fundación Ramón Areces

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC03191K

Reference123 articles.