N-Methyl deuterated rhodamines for protein labelling in sensitive fluorescence microscopy

Author:

Roßmann Kilian1ORCID,Akkaya Kerem C.1ORCID,Poc Pascal1ORCID,Charbonnier Corentin1ORCID,Eichhorst Jenny1,Gonschior Hannes1ORCID,Valavalkar Abha2ORCID,Wendler Nicolas3,Cordes Thorben3ORCID,Dietzek-Ivanšić Benjamin2ORCID,Jones Ben4ORCID,Lehmann Martin1ORCID,Broichhagen Johannes15ORCID

Affiliation:

1. Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Berlin, Germany

2. Leibniz Institute for Photonic Technology Jena e.V. (Leibniz-IPHT), Research Department Functional Interfaces, Jena, Germany

3. Physical and Synthetic Biology, Faculty of Biology, Ludwig-Maximilians-Universität München, Großhaderner Str. 2-4, Planegg-Martinsried, 82152, Germany

4. Section of Endocrinology and Investigative Medicine, Imperial College London, London W12 0NN, UK

5. Department of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany

Abstract

Deuteration enhances photophysical and chemical properties of fluorescent rhodamine dyes for higher brightness in sensitive microscopy.

Funder

H2020 European Research Council

Deutsche Forschungsgemeinschaft

Medical Research Council

European Association for the Study of Diabetes

Society for Endocrinology

British Society for Neuroendocrinology

NIHR Imperial Biomedical Research Centre

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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