A liquid chromatography electrospray ionization tandem mass spectrometric study (LC/ESI-MS/MS) of in vivo metabolites of cisplatin in rat liver and brain tissues: deuterated experiments-Reference-Cited by-同舟云学术

A liquid chromatography electrospray ionization tandem mass spectrometric study (LC/ESI-MS/MS) of in vivo metabolites of cisplatin in rat liver and brain tissues: deuterated experiments

Published:2015 Issue:109 Volume:5 Page:89951-89958
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bandu Raju¹²³⁴⁵,Kim Hak Jin⁶⁷⁸⁹¹⁰,Mok Hyuck Jun¹²³⁴⁵,Kim Kwang Pyo¹²³⁴⁵

Affiliation:

1. Department of Applied Chemistry

2. College of Applied Sciences

3. Kyung Hee University

4. Yong-in City

5. Korea

6. Department of Radiology

7. Pusan National University School of Medicine

8. Biomedical Research Institute

9. Pusan National University Hospital

10. Busan

Abstract

In vivo rat liver and brain tissue metabolites of an anticancer drug, cisplatin, have been identified and characterized by using LC/ESI-MS/MS in combination with on-line H/D exchange experiments.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA15237B

Reference33 articles.

1. Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns

2. Metabolite characterization of a novel anti-cancer agent, icotinib, in humans through liquid chromatography/quadrupole time-of-flight tandem mass spectrometry

3. Targeted profiling of polar intracellular metabolites using ion-pair-high performance liquid chromatography and -ultra high performance liquid chromatography coupled to tandem mass spectrometry: Applications to serum, urine and tissue extracts

4. Strategies for characterization of drug metabolites using liquid chromatography–tandem mass spectrometry in conjunction with chemical derivatization and on-line H/D exchange approaches

5. In electrospray ionization source hydrogen/deuterium exchange LC-MS and LC-MS/MS for characterization of metabolites

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