Biocatalytic retrosynthesis approaches tod-(2,4,5-trifluorophenyl)alanine, key precursor of the antidiabetic sitagliptin-Reference-Cited by-同舟云学术

Biocatalytic retrosynthesis approaches tod-(2,4,5-trifluorophenyl)alanine, key precursor of the antidiabetic sitagliptin

Published:2019 Issue:16 Volume:21 Page:4368-4379
ISSN:1463-9262
Container-title:Green Chemistry
language:en
Short-container-title:Green Chem.

Author:

Parmeggiani Fabio¹²³⁴⁵^ORCID,Rué Casamajo Arnau¹²³⁴⁵^ORCID,Colombo Danilo⁶⁷⁸⁹,Ghezzi Maria Chiara⁶⁷⁸⁹,Galman James L.¹²³⁴⁵^ORCID,Chica Roberto A.¹⁰¹¹¹²¹³¹⁴^ORCID,Brenna Elisabetta⁶⁷⁸⁹^ORCID,Turner Nicholas J.¹²³⁴⁵^ORCID

Affiliation:

1. Manchester Institute of Biotechnology (MIB)

2. School of Chemistry

3. University of Manchester

4. Manchester

5. UK

6. Dipartimento di Chimica

7. Materiali e Ingegneria Chimica “G. Natta”

8. Milano

9. Italy

10. Department of Chemistry and Biomolecular Sciences

11. Centre for Catalysis Research and Innovation

12. University of Ottawa

13. Ottawa

14. Canada

Abstract

Six chemo-enzymatic routes for the synthesis of a trifluorinatedd-phenylalanine have been described and compared, including the first example of a fully biocatalyticd-hydroamination.

Funder

H2020 European Research Council

Ontario Ministry of Economic Development and Innovation

Natural Sciences and Engineering Research Council of Canada

Canada Foundation for Innovation

Publisher

Royal Society of Chemistry (RSC)

Subject

Pollution,Environmental Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/GC/C9GC01902B

Reference48 articles.