Ultrafast amidation of esters using lithium amides under aerobic ambient temperature conditions in sustainable solvents-Reference-Cited by-同舟云学术

Ultrafast amidation of esters using lithium amides under aerobic ambient temperature conditions in sustainable solvents

Published:2020 Issue:25 Volume:11 Page:6500-6509
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Fairley Michael¹²³,Bole Leonie J.⁴⁵⁶⁷,Mulks Florian F.¹²³⁴⁵^ORCID,Main Laura¹²³,Kennedy Alan R.¹²³^ORCID,O'Hara Charles T.¹²³^ORCID,García-Alvarez Joaquín⁸⁹¹⁰¹¹¹²^ORCID,Hevia Eva¹²³⁴⁵^ORCID

Affiliation:

1. Department of Pure and Applied Chemistry

2. University of Strathclyde Glasgow

3. UK

4. Department für Chemie und Biochemie

5. Universität Bern

6. Bern

7. Switzerland

8. Laboratorio de Compuestos Organometálicos y Catálisis (Unidad Asociada al CSIC)

9. Centro de Innovación en Química Avanzada (ORFEO-CINQA)

10. Departamento de Química Orgánica e Inorgánica (IUQOEM)

11. Facultad de Química

12. Universidad de Oviedo

Abstract

Using 2-methyl THF as solvent enables efficient and ultrafast amidation of esters by lithium amides at room temperature in air, edging closer towards reaching air- and moisture-compatible polar organometallic chemistry.

Funder

Engineering and Physical Sciences Research Council

University of Strathclyde

Leverhulme Trust

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC01349H

Reference101 articles.

1. Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?