I2-Catalyzed Oxidative Acylation of Tertiary Amines via C–N Bond Cleavage-Reference-Cited by-同舟云学术

I2-Catalyzed Oxidative Acylation of Tertiary Amines via C–N Bond Cleavage

Published:2024-01-30 Issue:10 Volume:56 Page:1601-1607
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Ablajan Keyume^ORCID,Ge Xin¹,Lei Ping¹,Su Qin¹,Pan Ying-Ming²

Affiliation:

1. State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources, College of Chemistry, Xinjiang University

2. State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University

Abstract

AbstractThe development of catalysts for the amidation of tertiary amines with acyl chlorides through oxidative C–N bond cleavage is rather challenging. By employing iodine as the catalyst, a broad range of aromatic acyl chlorides and tertiary amines are efficiently converted into amides in good yields under mild conditions. A plausible mechanistic pathway is proposed for this transformation and is supported by appropriate control experiments.

Funder

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources

National Natural Science Foundation of China

Publisher

Georg Thieme Verlag KG

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2256-9837.pdf

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