Proline hydroxylation at different sites in hypoxia-inducible factor 1α modulates its interactions with the von Hippel–Lindau tumor suppressor protein-Reference-Cited by-同舟云学术

Proline hydroxylation at different sites in hypoxia-inducible factor 1α modulates its interactions with the von Hippel–Lindau tumor suppressor protein

Published:2018 Issue:27 Volume:20 Page:18756-18765
ISSN:1463-9076
Container-title:Physical Chemistry Chemical Physics
language:en
Short-container-title:Phys. Chem. Chem. Phys.

Author:

Qian Hongsheng¹²³⁴,Zou Yu¹²³⁴,Tang Yiming⁵⁶⁷⁴,Gong Yehong¹²³⁴,Qian Zhenyu⁸³⁴,Wei Guanghong⁵⁶⁷⁴^ORCID,Zhang Qingwen¹²³⁴^ORCID

Affiliation:

1. College of Physical Education and Training

2. Shanghai University of Sport

3. Shanghai 200438

4. China

5. State Key Laboratory of Surface Physics

6. Key Laboratory for Computational Physical Sciences (Ministry of Education), and Department of Physics, Collaborative Innovation Center of Advanced Microstructures (Nanjing), Fudan University

7. Shanghai 200433

8. Key Laboratory of Exercise and Health Sciences (Ministry of Education) and School of Kinesiology, Shanghai University of Sport

Abstract

Proline hydroxylation of HIF-1α affects the interaction affinity between pVHL and HIF-1α and allosterically induces the conformational change of pVHL.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CP/C8CP01964A

Reference51 articles.

1. HIF-1 and mechanisms of hypoxia sensing

2. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.