2-Benzylidenebenzofuran-3(2H)-ones as a new class of alkaline phosphatase inhibitors: synthesis, SAR analysis, enzyme inhibitory kinetics and computational studies

Author:

Ashraf Jamshaid1,Mughal Ehsan Ullah1ORCID,Alsantali Reem I.2,Sadiq Amina3,Jassas Rabab. S.4,Naeem Nafeesa1ORCID,Ashraf Zaman5,Nazir Yasir56,Zafar Muhammad Naveed7,Mumtaz Amara8,Mirzaei Masoud9ORCID,Saberi Satar10,Ahmed Saleh A.1112

Affiliation:

1. Department of Chemistry, University of Gujrat, Gujrat-50700, Pakistan

2. Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

3. Department of Chemistry, Govt. College Women University, Sialkot-51300, Pakistan

4. Department of Chemistry, Jamoum University College, Umm Al-Qura University, 21955 Makkah, Saudi Arabia

5. Department of Chemistry, Allama Iqbal Open University, Islamabad-44000, Pakistan

6. Department of Chemistry, University of Sialkot, Sialkot-51300, Pakistan

7. Department of Chemistry, Quaid-i-Azam University, Islamabad-45320, Pakistan

8. Department of Chemistry, COMSATS University Islamabad, Abbottabad, Pakistan

9. Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Mashhad-9177948974, Iran

10. Department of Chemistry, Faculty of Science, Farhangian University, Tehran, Iran

11. Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, 21955 Makkah, Saudi Arabia

12. Chemistry Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt

Abstract

Aurones are the plant secondary metabolites belonging to the flavonoid’s family. The bioactivities of aurones are very promising, thus these heterocyclic compounds can be considered as an alluring scaffold for drug design and development.

Funder

Taif University

Higher Education Commission, Pakistan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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