Rational design of cell active C2-modified DGJ analogues for the inhibition of human α-galactosidase A (GALA)-Reference-Cited by-同舟云学术

Rational design of cell active C2-modified DGJ analogues for the inhibition of human α-galactosidase A (GALA)

Published:2021 Issue:37 Volume:19 Page:8057-8062
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Ashmus Roger A.¹^ORCID,Wang Yang¹,González-Cuesta Manuel²,King Dustin T.³,Tiet Ben¹,Gilormini Pierre-André¹^ORCID,García Fernández José M.⁴^ORCID,Ortiz Mellet Carmen²^ORCID,Britton Robert¹^ORCID,Vocadlo David J.¹³^ORCID

Affiliation:

1. Department of Chemistry and Simon Fraser University, Burnaby, British Columbia, Canada

2. Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Sevilla 41012, Spain

3. Department of Molecular Biology and Biochemistry Simon Fraser University, Burnaby, British Columbia, Canada

4. Instituto de Investigaciones Químicas (IIQ), CSIC-Universidad de Sevilla, Sevilla 41092, Spain

Abstract

A selective inhibitor of GALA reduces Gb3 levels by over half within Fabry disease patient fibroblasts.

Funder

Canadian Institutes of Health Research

Canada Research Chairs

Ministerio de Ciencia, Innovación y Universidades

Natural Sciences and Engineering Research Council of Canada

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D1OB01526E

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