Structurally diverse arene-fused ten-membered lactams accessed via hydrolytic imidazoline ring expansion-Reference-Cited by-同舟云学术

Structurally diverse arene-fused ten-membered lactams accessed via hydrolytic imidazoline ring expansion

Published:2017 Issue:14 Volume:15 Page:2906-2909
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Sapegin Alexander¹²³⁴,Osipyan Angelina¹²³⁴,Krasavin Mikhail¹²³⁴^ORCID

Affiliation:

1. Institute of Chemistry

2. Saint Petersburg State University

3. Peterhof 198504

4. Russia

Abstract

A facile approach to hitherto unknown ten-membered ring systems via a hydrolytic imidazoline ring expansion (HIRE) is described. Medium-sized rings are scarce in the contemporary medicinal chemistry toolbox. The new HIRE strategy broadens the arsenal of synthetic methods to obtain such scaffolds.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00535K

Reference29 articles.

1. Ring-Expansion Approach to Medium-Sized Lactams and Analysis of Their Medicinal Lead-Like Properties

2. Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

3. An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors