Preparation of von Hippel-Lindau (VHL) E3 ubiquitin ligase ligands exploiting constitutive hydroxyproline for benzylic amine protection-Reference-Cited by-同舟云学术

登录注册会员服务联系我们

Preparation of von Hippel-Lindau (VHL) E3 ubiquitin ligase ligands exploiting constitutive hydroxyproline for benzylic amine protection

Published:2024 Issue:24 Volume:14 Page:17077-17090
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Soto-Martínez Diana M.¹^ORCID,Clements Garrett D.¹^ORCID,Díaz John E.¹,Becher Joy¹^ORCID,Reynolds Robert C.²,Ochsenbauer Christina²,Snowden Timothy S.¹³^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, The University of Alabama, 250 Hackberry Lane, Tuscaloosa, AL 35487, USA

2. Department of Medicine, Division of Hematology and Oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA

3. Center for Convergent Bioscience and Medicine, The University of Alabama, 720 2nd St., Tuscaloosa, AL 35401, USA

Abstract

Step economical routes for the multigram preparation of popular VHL E3 ligase recruiting ligands.

Funder

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA01974A

Reference32 articles.

1. PROTAC targeted protein degraders: the past is prologue

2. Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders

3. Journey of Von Hippel-Lindau (VHL) E3 ligase in PROTACs design: From VHL ligands to VHL-based degraders

4. Physicochemical Property Determinants of Oral Absorption for PROTAC Protein Degraders

5. Current advances of small molecule E3 ligands for proteolysis-targeting chimeras design

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370

www.globalauthorid.com

TOP