Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders-Reference-Cited by-同舟云学术

Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders

Published:2022 Issue:19 Volume:51 Page:8216-8257
ISSN:0306-0012
Container-title:Chemical Society Reviews
language:en
Short-container-title:Chem. Soc. Rev.

Author:

Diehl Claudia J.¹^ORCID,Ciulli Alessio¹^ORCID

Affiliation:

1. Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, Dundee, Scotland, UK

Abstract

This review provides a comprehensive overview of the structure-based design of small-molecule VHL ligands and their applications as VHL inhibitors and E3 ligase recruiting moieties in PROTAC degraders.

Funder

H2020 Marie Skłodowska-Curie Actions

FP7 Ideas: European Research Council

Biotechnology and Biological Sciences Research Council

Innovative Medicines Initiative

FP7 People: Marie-Curie Actions

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CS/D2CS00387B

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