Nanodisc reconstitution of flavin mononucleotide binding domain of cytochrome-P450-reductase enables high-resolution NMR probing-Reference-Cited by-同舟云学术

Nanodisc reconstitution of flavin mononucleotide binding domain of cytochrome-P450-reductase enables high-resolution NMR probing

Published:2021 Issue:39 Volume:57 Page:4819-4822
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Krishnarjuna Bankala¹²³⁴⁵^ORCID,Yamazaki Toshio⁶⁷⁸,Anantharamaiah G. M.⁹¹⁰¹¹¹²,Ramamoorthy Ayyalusamy¹²³⁴⁵^ORCID

Affiliation:

1. Biophysics Program

2. Department of Chemistry

3. Biomedical Engineering

4. Macromolecular Science and Engineering

5. University of Michigan

6. RIKEN Center for Biosystems Dynamics Research

7. Yokohama City

8. Japan

9. Department of Medicine

10. University of Alabama at Birmingham Medical Center

11. Birmingham

12. USA

Abstract

Reconstitution of the flavin mononucleotide binding domain of cyt-P450-reductase in peptide-lipid-nanodiscs provided a stable conformation that assisted in mapping transient lipid-protein interactions and line broadening through chemical shift analysis.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2021/CC/D1CC01018B

Reference27 articles.

1. Cytochrome P450 research and The Journal of Biological Chemistry

2. Metabolism and Interactions of Chloroquine and Hydroxychloroquine with Human Cytochrome P450 Enzymes and Drug Transporters

3. Ligand Binding to Cytochrome P450 3A4 in Phospholipid Bilayer Nanodiscs

4. Structural and Functional Studies of the Membrane-Binding Domain of NADPH-Cytochrome P450 Oxidoreductase

5. Organization of multiple cytochrome P450s with NADPH-cytochrome P450 reductase in membranes

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