Photocatalyst- and additive-free decarboxylative alkylation of N-aryl tetrahydroisoquinolines induced by visible light

Author:

Ma Pengju12345,Liu Yufei12345,Chen Lingling12345,Zhao Xu6789ORCID,Yang Bo12345ORCID,Zhang Junmin12345ORCID

Affiliation:

1. International Joint Research Center for Molecular Science

2. College of Chemistry and Environmental Engineering

3. Shenzhen University

4. Shenzhen

5. P. R. China

6. Research Center for Eco-Environmental Sciences

7. Chinese Academy of Sciences

8. Beijing 100085

9. China

Abstract

A photocatalyst- and additive-free visible light induced decarboxylative alkylation of N-aryl tetrahydroisoquinolines has been developed using tetrachloro-N-hydroxyphthalimide esters as alkylation agents.

Funder

National Natural Science Foundation of China

Department of Education of Guangdong Province

Science and Technology Foundation of Shenzhen City

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Reference81 articles.

1. M.Shamma , The Isoquinoline Alkaloids Chemistry and Pharmacology , Academic Press , New York , 1972

2. Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics

3. L.Yet , Tetrahydroisoquinolines in Privileged Structures in Drug Discovery: Medicinal Chemistry and Synthesis , John Wiley & Sons, Inc. , 1st edn, 2018 , pp. 356–413

4. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals

5. Asymmetric Synthesis of Isoquinoline Alkaloids

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