Crystal structures capture multiple stoichiometric states of an aqueous self-assembling oligourea foldamer

Author:

Collie Gavin W.1ORCID,Lombardo Caterina M.2,Yoo Sung Hyun2ORCID,Pułka-Ziach Karolina3ORCID,Gabelica Valérie4ORCID,Mackereth Cameron D.4ORCID,Rosu Frédéric5ORCID,Guichard Gilles2ORCID

Affiliation:

1. Discovery Sciences, R&D, AstraZeneca, Cambridge, UK

2. Univ. Bordeaux, CNRS, Bordeaux INP, CBMN, UMR 5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607, Pessac, France

3. University of Warsaw, Faculty of Chemistry, Pasteura 1, 02-093, Warsaw, Poland

4. Univ. Bordeaux, CNRS, INSERM, ARNA, UMR 5320, U1212, IECB, F-33600 Bordeaux, France

5. Univ. Bordeaux, CNRS, INSERM, IECB, UMS 3033, F-33600 Pessac, France

Abstract

We describe here an oligourea foldamer able to self-assemble in aqueous conditions into helix bundles of multiple stoichiometries, with accompanying crystal structures providing high-resolution details of the structural polymorphism of this foldamer.

Funder

European Commission

Agence Nationale de la Recherche

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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