Tuning the peroxidase activity of artificial P450 peroxygenase by engineering redox-sensitive residues-Reference-Cited by-同舟云学术

Tuning the peroxidase activity of artificial P450 peroxygenase by engineering redox-sensitive residues

Published:2024 Issue: Volume:252 Page:52-68
ISSN:1359-6640
Container-title:Faraday Discussions
language:en
Short-container-title:Faraday Discuss.

Author:

Jiang Fengjie¹²,Wang Zihan¹²^ORCID,Cong Zhiqi¹²³⁴^ORCID

Affiliation:

1. CAS Key Laboratory of Biofuels and Shandong Provincial Key Laboratory of Synthetic Biology, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China

2. University of Chinese Academy of Sciences, Beijing 100049, China

3. Shandong Energy Institute, Qingdao 266101, China

4. Qingdao New Energy Shandong Laboratory, Qingdao 266101, China

Abstract

Engineering redox-sensitive residues dramatically increases the peroxidase activity of P450BM3 monooxygenase, providing new insights and a strategy for regulating P450s' promiscuous functionality.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/FD/D4FD00008K

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