Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands-Reference-Cited by-同舟云学术

Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands

Published:2020 Issue:39 Volume:56 Page:5291-5294
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Braganza Chriselle D.¹²³⁴,Motozono Chihiro⁵⁶⁷⁸⁹,Sonoda Koh-Hei¹⁰¹¹¹²¹³⁹,Yamasaki Sho⁵⁶⁷⁸⁹,Shibata Kensuke¹⁰¹¹¹²¹³⁹,Timmer Mattie S. M.¹²³⁴^ORCID,Stocker Bridget L.¹²³⁴

Affiliation:

1. School of Chemical and Physical Sciences

2. Victoria University of Wellington

3. Wellington

4. New Zealand

5. Department of Molecular Immunology

6. Research Institute for Microbial Diseases

7. Osaka University

8. Osaka

9. Japan

10. Department of Ocular Pathology and Imaging Science

11. Graduate School of Medical Sciences

12. Kyushu University

13. Fukuoka

Abstract

The 6-alkylamino side chain of aminouracil MR1 ligands controls MAIT cell agonistic or antagonistic activity.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/CC/D0CC00247J

Reference15 articles.

1. An Invariant T Cell Receptor α Chain Defines a Novel TAP-independent Major Histocompatibility Complex Class Ib–restricted α/β T Cell Subpopulation in Mammals

2. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1

3. The biology and functional importance of MAIT cells

4. A Highly Conserved Major Histocompatibility Complex Class I-Related Gene in Mammals

5. MR1 presents microbial vitamin B metabolites to MAIT cells

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