A facile hybrid ‘flow and batch’ access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones-Reference-Cited by-同舟云学术

A facile hybrid ‘flow and batch’ access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones

Published:2016 Issue:37 Volume:14 Page:8732-8742
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Lin Andrew J. S.¹²³⁴⁵,Russell Cecilia C.¹²³⁴⁵,Baker Jennifer R.¹²³⁴⁵,Frailey Shelby L.¹²³⁴⁵,Sakoff Jennette A.⁶⁷⁸⁹,McCluskey Adam¹²³⁴⁵

Affiliation:

1. Chemistry

2. Centre for Chemical Biology

3. School of Environmental & Life Sciences

4. University of Newcastle

5. University Drive

6. Department of Medical Oncology

7. Calvary Mater Newcastle Hospital

8. Waratah

9. Australia

Abstract

A simple flow chemistry approach to libraries of 2-substituted-phenylamino 3,4-dihydro-2H-benzo[b][1,4]oxazine-6-carboxylates (12a–l and 13a–l) in 38–87% yields.

Funder

Australian Cancer Research Foundation

Australian Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C6OB01153E

Reference27 articles.

1. The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates

2. What Do Medicinal Chemists Actually Make? A 50-Year Retrospective

3. Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

4. Recent advances in the synthesis of 2H-1,4-benzoxazin-3-(4H)-ones and 3,4-dihydro-2H-1,4-benzoxazines

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