On the kinetics of solvate formation through mechanochemistry

Author:

Hasa Dritan1234ORCID,Pastore Mariana5678,Arhangelskis Mihails9101112ORCID,Gabriele Benjamin1314154,Cruz-Cabeza Aurora J.1314154ORCID,Rauber Gabriela Schneider916174ORCID,Bond Andrew D.916174ORCID,Jones William916174

Affiliation:

1. Leicester School of Pharmacy

2. De Montfort University

3. LE1 9BH Leicester

4. UK

5. Department of Chemical and Pharmaceutical Sciences

6. University of Trieste

7. 34127 Trieste

8. Italy

9. Department of Chemistry

10. McGill University

11. Montreal

12. Canada

13. School of Chemical Engineering and Analytical Science

14. University of Manchester

15. Manchester

16. University of Cambridge

17. CB2 1EW Cambridge

Abstract

We demonstrate that solvates obtained through mechanochemistry are the thermodynamic products, and that the kinetics of solvate formation are related to the easiness of breaking the reactant crystals.

Funder

AbbVie

University of Manchester

Roche

Royal Society

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Reference42 articles.

1. U. J. Griesser , in Polymorphism: in the Pharmaceutical Industry , ed. R. Hilfiker , Wiley-VCH Verlag GmbH & Co. KGaA , Weinheim, Germany , 2006 , ch. 8, pp. 211–233

2. Polymorphism and Solvatomorphism 2010

3. Specialized Solid Form Screening Techniques

4. Analysis of organic polymorphs. A review

5. High-pressure recrystallisation—a route to new polymorphs and solvates

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