Controlling desolvation through polymer-assisted grinding

Author:

Terban Maxwell W.1ORCID,Madhau Leillah2,Cruz-Cabeza Aurora J.3ORCID,Okeyo Peter O.45,Etter Martin6ORCID,Schulz Armin1,Rantanen Jukka4ORCID,Dinnebier Robert E.1ORCID,Billinge Simon J. L.78ORCID,Moneghini Mariarosa9,Hasa Dritan9ORCID

Affiliation:

1. Max Planck Institute for Solid State Research, Heisenbergstraße 1, 70569 Stuttgart, Germany

2. Leicester School of Pharmacy, De Montfort University, The Gateway, LE1 9BH, Leicester, UK

3. Department of Chemical Engineering and Analytical Science, University of Manchester, Manchester M13 9PL, UK

4. Department of Pharmacy, University of Copenhagen, Universitetsparken 2, Copenhagen, 2100, Denmark

5. Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark, 2800, Kongens Lyngby, Denmark

6. Deutsches Elektronen Synchrotron (DESY), Notkestraße 85, 22607 Hamburg, Germany

7. Department of Applied Physics and Applied Mathematics, Columbia University, New York, 10027, USA

8. Condensed Matter Physics and Materials Science Department, Brookhaven National Laboratory, Upton, NY 11973, USA

9. Department of Chemical and Pharmaceutical Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy

Abstract

The ability to controllably desolvate a crystal-solvate system in a step-wise fashion through polymer-assisted grinding is demonstrated by varying the type and proportion of polymer agent used.

Funder

Danmarks Grundforskningsfond

Velux Fonden

U.S. Department of Energy

Det Frie Forskningsråd

Università degli Studi di Trieste

BASF

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

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